Placental epigenetic clocks: relations with in-utero exposures, ancestry, and fetal growth
نویسندگان
چکیده
منابع مشابه
Oxygenation In Utero: Placental Determinants and Fetal Requirements
Oxygen is an essential substrate for life before birth; it is required to produce energy, maintain tissues already laid down, and support accretion of new tissues. Fetal oxygen requirements are therefore ultimately determined by the rate of fetal growth and the factors that regulate this process. These needs clearly vary with body size, composition, and metabolic activity, and therefore with st...
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INTRODUCTION Ultrasonic fetal biometry and arterial Doppler flow velocimetry are widely used to assess the risk of pregnancy complications. There is an extensive literature on the relationship between pregnancy outcomes and the size and shape of the placenta. However, ultrasonic fetal biometry and arterial Doppler flow velocimetry have not previously been studied in relation to postnatal placen...
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This review considers mechanisms by which transfer across the placenta takes place and how the capacity of the placenta to supply nutrients relates to fetal growth and vice versa. Blood flow through both uterine and umbilical circulations of the placenta, the structural properties of the placental exchange barrier and its related diffusional permeability, and the expression and activity of a wi...
متن کاملConfined placental mosaicism and intrauterine fetal growth.
Fetal growth is a complex and dynamic process regulated by a large number of interactive factors of fetal, maternal, and placental origin. As a result, any abnormality of fetal growth has a complex multifactorial pathogenesis. It has been estimated that about 50% of intrauterine fetal growth is determined by fetal genes. Maternal disease, her nutritional intake and behaviours, such as smoking, ...
متن کاملAltered fetal growth, placental abnormalities, and stillbirth
BACKGROUND Worldwide, stillbirth is one of the leading causes of death. Altered fetal growth and placental abnormalities are the strongest and most prevalent known risk factors for stillbirth. The aim of this study was to identify patterns of association between placental abnormalities, fetal growth, and stillbirth. METHODS AND FINDINGS Population-based case-control study of all stillbirths a...
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ژورنال
عنوان ژورنال: ISEE Conference Abstracts
سال: 2020
ISSN: 1078-0475
DOI: 10.1289/isee.2020.virtual.o-sy-1523